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Apr 22, 2012 | Cook JL, Stoker SM, Lerner A, Totterman S, Cook CR, Fox DB

Correlating Biochemical, Histologic, and Magnetic Resonance Imaging Measures for Early Diagnosis of Osteoarthritis in the Pondnuki Model in Dogs

Although there are currently ways to assess articular cartilage degradation in osteoarthritis (OA) these measurements usually cannot be completed currently in a noninvasive, clinically ­relevant manner. Magnetic resonance imaging (MRI), however, is readily available, noninvasive, and shows promise for assessing early articular cartilage degradation. If MRI can be used to consistently and accurately predict the extent and severity of cartilage degradation in the early, potentially reversible stages of disease, preventative and therapeutic strategies for OA would be greatly enhanced.

Download this publication to discover how MRI can accurately assess early articular cartilage degradation by “gold standard” histologic and biochemical measures. Questions addressed include:

  • Can articular cartilage degradation in OA be assessed by MRI, prior to gross evidence of pathology?
  • Does MRI directly correlate to biochemical and histologic changes associated with early OA?
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