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Aug 3, 2014 | Steven Troy, Virginia Parks, Jaideep Purkayastha, Sophie Gossart, Daniel B. Goodman, Heinrich Achenbach, Martin Armstrong, and Patrick T. Martin

Effect of Anagrelide on Cardiac Repolarization in Healthy Volunteers: A Randomized, Double-Blind, Placebo- and Positive-Controlled, Thorough QT Study

The assessment of drug-induced changes in the QT and QTc interval has become a necessary component of drug development. This is because of the potential for new drugs with suspected or known effects on the heart to cause life-threatening delayed cardiac repolarization.

A study was conducted to evaluate the effects of low and high therapeutic single doses of anagrelide on the QT/QTc interval. 60 healthy volunteers were enrolled into a randomized, double-blind, crossover trial.

Download the publication to discover the results of the study, including the methods used for:

  • Trial design
  • Participants
  • Interventions
  • Assessments
  • Endpoints
  • Statistical approach
  • Pharmacokinetics

 

Download