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MCOT® Clinical Publications

Mobile Cardiac Outpatient Telemetry
Peer-reviewed published clinical studies validating the efficacy and value of MCOT
MCOT

First experience with a Mobile Cardiac Outpatient Telemetry (MCOT) system for the diagnosis and management of cardiac arrhythmia

Authors
Ajay K. Joshi, MD, Peter R. Kowey, MD, Eric N. Prystowsky, MD, David G. Benditt, MD, David S. Cannom, MD, Craig M. Pratt, MD, Anna McNamara, RN, and Robert M. Sangrigoli, MD.
Source
American Journal of Cardiology (April 1, 2005; 95:878-881)
Study Results
  • MCOT. – . n o i t n e v r e t n i t n e m t a e r t d e r i u q e r s t n e i t a p f o % 4 3 – , s n o i t a l b a 4 , s r e k a m e c a p 5 ( e r u d e c o r p l a c i g r u s d e r i u q e r % 2 1 2 ICD implants). – 1/3 of all patients had prior testing with an event or Holter. • and management of patients with suspected arrhythmias. Retrospective analysis of the first 100 patients monitored on MCOT.
  • 34% of patients required treatment intervention.
  • 12% required surgical procedure (5 pacemakers, 4 ablations, 2 ICD implants).
  • 1/3 of all patients had prior testing with an event or Holter.
  • MCOT. – . n o i t n e v r e t n i t n e m t a e r t d e r i u q e r s t n e i t a p f o % 4 3 – , s n o i t a l b a 4 , s r e k a m e c a p 5 ( e r u d e c o r p l a c i g r u s d e r i u q e r % 2 1 2 ICD implants). – 1/3 of all patients had prior testing with an event or Holter. • and management of patients with suspected arrhythmias. MCOT finds arrhythmias that other modalities have failed to capture, and is a clinically useful, first-line tool for diagnosis and management of patients with suspected arrhythmias.
THE DIAGNOSIS OF CARDIAC ARRHYTHMIAS:

A prospective multi-center randomized study comparing Mobile Cardiac Outpatient Telemetry versus standard loop event monitoring

Authors
Steven A. Rothman, M.D.,* James C. Laughlin, M.D.,* Jonathan Seltzer, M.D.,*,†Jasjit S. Walia, M.B.B.S.,‡ Rakesh I. Baman, M.D., Samer Y. Siouffi, M.D.,§ Robert M. Sangrigoli, M.D.,# and Peter R. Kowey, M.D.*
Source
Journal of Cardiovascular Electrophysiology Vol. 18, No. 3, March 2007 
Study Results
  • MCOT. – . n o i t n e v r e t n i t n e m t a e r t d e r i u q e r s t n e i t a p f o % 4 3 – , s n o i t a l b a 4 , s r e k a m e c a p 5 ( e r u d e c o r p l a c i g r u s d e r i u q e r % 2 1 2 ICD implants). – 1/3 of all patients had prior testing with an event or Holter. • and management of patients with suspected arrhythmias. Purpose of study was to compare the relative value of MCOT with a patient-activated loop recorder in a randomized control trial.
  • MCOT. – . n o i t n e v r e t n i t n e m t a e r t d e r i u q e r s t n e i t a p f o % 4 3 – , s n o i t a l b a 4 , s r e k a m e c a p 5 ( e r u d e c o r p l a c i g r u s d e r i u q e r % 2 1 2 ICD implants). – 1/3 of all patients had prior testing with an event or Holter. • and management of patients with suspected arrhythmias. 17-center, 305-subject, prospective parallel clinical trial with patients randomized to either LOOP or MCOT monitors.
  • MCOT. – . n o i t n e v r e t n i t n e m t a e r t d e r i u q e r s t n e i t a p f o % 4 3 – , s n o i t a l b a 4 , s r e k a m e c a p 5 ( e r u d e c o r p l a c i g r u s d e r i u q e r % 2 1 2 ICD implants). – 1/3 of all patients had prior testing with an event or Holter. • and management of patients with suspected arrhythmias. MCOT made a diagnosis in 88%, LOOP in 75%.
  • Syncope or pre-syncope subgroup: Diagnosis made in 89% of MCOT patients and 69% of LOOP patients.
From the * Lankenau Hospital and Institute for Medical Research/Main Line Health Heart Center, Wynnewood, PA, ‡ University of Medicine and Dentistry of New Jersey, New Brunswick, NJ, ¶ Pottstown Memorial Medical Center, Pottstown, PA, § Mercy Hospital, Pittsburgh, PA, # Doylestown Memorial Hospital, Doylestown, PA, and † Applied Clinical Intelligence, Philadelphia, PA, USA
UNIVERSITY OF PENNSYLVANIA STUDY

Predictors of finding occult atrial fibrillation after cryptogenic stroke

Authors
Christopher G. Favilla, MD*; Erin Ingala, MD*; Jenny Jara, BA; Emily Fessler, BA; Brett Cucchiara, MD; Steven R. Messé, MD; Michael T. Mullen, MD; Allyson Prasad, CRNP; James Siegler, MD; Mathew D. Hutchinson, MD; Scott E. Kasner, MD. From the Department of Neurology and Division of Cardiology at University of Pennsylvania .
*Drs. Favilla and Ingala contibuted equally
Source
stroke. 2015;46:1210-1215. DOI:10.1161/STROKEAHA.114.007763. https://www.ahajournals.org/ doi/10.1161/STROKEAHA.114.007763
Study Results
  • MCOT. – . n o i t n e v r e t n i t n e m t a e r t d e r i u q e r s t n e i t a p f o % 4 3 – , s n o i t a l b a 4 , s r e k a m e c a p 5 ( e r u d e c o r p l a c i g r u s d e r i u q e r % 2 1 2 ICD implants). – 1/3 of all patients had prior testing with an event or Holter. • and management of patients with suspected arrhythmias. 28-day MCOT detected AF in a substantial proportion (14%) of cryptogenic stroke patients.
  • MCOT. – . n o i t n e v r e t n i t n e m t a e r t d e r i u q e r s t n e i t a p f o % 4 3 – , s n o i t a l b a 4 , s r e k a m e c a p 5 ( e r u d e c o r p l a c i g r u s d e r i u q e r % 2 1 2 ICD implants). – 1/3 of all patients had prior testing with an event or Holter. • and management of patients with suspected arrhythmias. 250 patients in a single center study - retrospective analysis of patients who underwent a 28 day MCOT.
  • MCOT. – . n o i t n e v r e t n i t n e m t a e r t d e r i u q e r s t n e i t a p f o % 4 3 – , s n o i t a l b a 4 , s r e k a m e c a p 5 ( e r u d e c o r p l a c i g r u s d e r i u q e r % 2 1 2 ICD implants). – 1/3 of all patients had prior testing with an event or Holter. • and management of patients with suspected arrhythmias. 84% (26 patients) were anticoagulated regardless of AF episode duration. All patients without bleeding history were offered anticoagulation regardless of duration of AF.
CASE-CONTROL STUDY

Paroxysmal atrial fibrillation in cryptogenic stroke

Authors
Alejandro A. Rabenstein, MD,* Jennifer E. Fugate, DO,* Jay Mandrekar, PhD,† Joseph D. Burns, MD,*‡ Raymond C.S. Seet, MD,*§ Stefan A. Dupont, MD,* || Timothy J. Kauffman, MD,¶ Samuel J. Asirvatham, MD,** and Paul A. Friedman, MD**
Source
Journal of Stroke and Cerebrovascular Diseases, 2013
Study Results
  • MCOT. – . n o i t n e v r e t n i t n e m t a e r t d e r i u q e r s t n e i t a p f o % 4 3 – , s n o i t a l b a 4 , s r e k a m e c a p 5 ( e r u d e c o r p l a c i g r u s d e r i u q e r % 2 1 2 ICD implants). – 1/3 of all patients had prior testing with an event or Holter. • and management of patients with suspected arrhythmias. 128 patients enrolled within 3 months of suffering first stroke.
  • MCOT. – . n o i t n e v r e t n i t n e m t a e r t d e r i u q e r s t n e i t a p f o % 4 3 – , s n o i t a l b a 4 , s r e k a m e c a p 5 ( e r u d e c o r p l a c i g r u s d e r i u q e r % 2 1 2 ICD implants). – 1/3 of all patients had prior testing with an event or Holter. • and management of patients with suspected arrhythmias. Paroxysmal Atrial Fibrillation (PAF) of any duration detected in 25% of total patients with MCOT monitoring.
  • MCOT. – . n o i t n e v r e t n i t n e m t a e r t d e r i u q e r s t n e i t a p f o % 4 3 – , s n o i t a l b a 4 , s r e k a m e c a p 5 ( e r u d e c o r p l a c i g r u s d e r i u q e r % 2 1 2 ICD implants). – 1/3 of all patients had prior testing with an event or Holter. • and management of patients with suspected arrhythmias. ALL episodes were asymptomatic.
  • MCOT. – . n o i t n e v r e t n i t n e m t a e r t d e r i u q e r s t n e i t a p f o % 4 3 – , s n o i t a l b a 4 , s r e k a m e c a p 5 ( e r u d e c o r p l a c i g r u s d e r i u q e r % 2 1 2 ICD implants). – 1/3 of all patients had prior testing with an event or Holter. • and management of patients with suspected arrhythmias. Nearly 20% of all patients (1 in 5) had AF detected in < 30 second episodes.
From the *Department of Neurology, Mayo Clinic, Rochester, MN; †Department of biomedical Statistics, May Clinic, Rochester, MN; ‡Department of Neurology, Boston University, Boston, MA, §Department of Neurology, National University of Singapore, Singapore, Singapore; ||Department of Neurology, Cleveland Clinic, Cleveland, OH; ¶Department of Radiology, Mayo Clinic, Rochester, MN
MCOT

Atrial fibrillation detected by Mobile Cardiac Outpatient Telemetry (MCOT) in cryptogenic TIA or stroke

Authors
A.H Tayal, MD; M. Tian, RN; K.M Kelly, MD, PhD; S.C. Jones, PhD; D.G.Wright, MD; D. Singh, MD; J. Jarouse, CRNP; J. Brillman, MD; S. Murali, MD; R. Gupta, MD
Source
Neurology®
Volume 71, Number 21, November 2008
Study Results
  • MCOT. – . n o i t n e v r e t n i t n e m t a e r t d e r i u q e r s t n e i t a p f o % 4 3 – , s n o i t a l b a 4 , s r e k a m e c a p 5 ( e r u d e c o r p l a c i g r u s d e r i u q e r % 2 1 2 ICD implants). – 1/3 of all patients had prior testing with an event or Holter. • and management of patients with suspected arrhythmias. 68 patients in a single center study —retrospective analysis of patients who underwent a 21 day MCOT.
  • MCOT. – . n o i t n e v r e t n i t n e m t a e r t d e r i u q e r s t n e i t a p f o % 4 3 – , s n o i t a l b a 4 , s r e k a m e c a p 5 ( e r u d e c o r p l a c i g r u s d e r i u q e r % 2 1 2 ICD implants). – 1/3 of all patients had prior testing with an event or Holter. •