Alzheimer’s disease (AD), a neurodegenerative disorder associated with progressive functional decline, is initially diagnosed as a memory disorder accompanied by attentional and perceptual deficits. The perceptual deficits associated with AD include impaired visual motion processing with elevated thresholds for optic flow – the patterned visual motion seen during an observer self-movement. A study was conducted to validate diffusion tensor imaging (DTI) as a new diagnostic tool for early AD. Download the publication to discover: The initial findings obtained with DTI in AD patients and age-matched controls, for the corpus callosum alone How the integrity of white matter correlates with performance on some neuropsychological tests

Although there are currently ways to assess articular cartilage degradation in osteoarthritis (OA) these measurements usually cannot be completed currently in a noninvasive, clinically ­relevant manner. Magnetic resonance imaging (MRI), however, is readily available, noninvasive, and shows promise for assessing early articular cartilage degradation. If MRI can be used to consistently and accurately predict the extent and severity of cartilage degradation in the early, potentially reversible stages of disease, preventative and therapeutic strategies for OA would be greatly enhanced. Download this publication to discover how MRI can accurately assess early articular cartilage degradation by “gold standard” histologic and biochemical measures. Questions addressed include: Can articular cartilage degradation in OA be assessed by MRI, prior to gross evidence of pathology? Does MRI directly correlate to biochemical and

Many patients who have benefited from effective chemotherapy now face increased risks of morbidity and mortality from acute and delayed toxic effects of chemotherapeutic agents. Cardiotoxicity has become one of the most important complications of cancer chemotherapy, therefore, assessment of cardiac function should be part of every Phase I through Phase III clinical trial of anti-tumor agents in development. Download our white paper to discover major cardiotoxicity biomarkers during oncology development, including: Two dimensional & doppler echocardiography Multi-gated acquisition scans 12-Lead electrocardiography Role of the cardiac core laboratory

Post-dialysis fatigue (PDF) is a common, debilitating symptom that remains poorly understood. Cardiac wall motion abnormalities (WMAs) may worsen during dialysis, but it is unknown whether WMAs are associated with PDF. To determine whether worsened intradialytic WMAs were associated with symptoms during or after dialysis, a study was conducted on 40 patients. Download the publication to discover the results of the study, including: Protocol development Measurement predictors Outcomes Statistical analysis

Loxapine, which was introduced more than 35 years ago in the US, Canada, and Europe, has a well-established efficacy and safety profile in the treatment of schizophrenia. Although it was approved by the FDA, a thorough QT/QTc study had not been conducted for loxapine. To establish the effects of inhaled loxapine on the QTc interval in a randomized, placebo-controlled, double-blind crossover trial, 48 healthy volunteers received a single inhaled placebo or 10mg loxapine to test the effects. Download the publication to discover the key findings of the study, including: Study design and medication ECG recording, analysis and interpretation Statistical analysis Relationship between QT interval and loxapine

The assessment of drug-induced changes in the QT and QTc interval has become a necessary component of drug development. This is because of the potential for new drugs with suspected or known effects on the heart to cause life-threatening delayed cardiac repolarization. A study was conducted to evaluate the effects of low and high therapeutic single doses of anagrelide on the QT/QTc interval. 60 healthy volunteers were enrolled into a randomized, double-blind, crossover trial. Download the publication to discover the results of the study, including the methods used for: Trial design Participants Interventions Assessments Endpoints Statistical approach Pharmacokinetics  

BioTelemetry Research performed a blinded reading to define the variability between inter-reader and intra-reader assessments. The reading was conducted for 58 ECHO studies by two physicians and 29 ECHOs re-read by the same reader. Download our white paper to discover the findings between inter-reader and intra-reader variability for several ECHO Cardiogram parameters, including: Protocol information ECHO parameters analysis ECHO methodology Statistical methods Results and key findings

Non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatisis (NASH) are emerging as the most prevalent causes of liver disease in Western countries. There are various methods used to evaluate fat content as well as other characteristics of the liver. Medical imaging provides a non-invasive approach to quantify tissue characteristics of the liver while reducing errors in diagnosis and disease staging. Download our white paper to discover: The causes of NAFLD and NASH Symptoms and disease progression Diagnosis, treatment and evaluation of liver fat How to use Ultrasound, CT imaging, MR spectroscopy and MR imaging techniques for assessing liver fat content As a leader of hepatic fat imaging and quantification, our team will work with you to determine the imaging modality, acquisition protocol and analysis method that will best serve your study.

Immunotherapy is an emerging class of cancer treatment, which stimulates the body’s immune system to fight cancer. With the approval of three checkpoint inhibitors (ipilimumab, pembrolizumab and nivolumab) by the FDA in the past five years, immunotherapies are seen as exciting treatments able to elicit durable cures. Download our white paper to discover: Emerging immunotherapeutic approaches to treat cancer Adoptive cell transfer Anticancer vaccines Oncolytic viruses Let our team support you with identifying new ways to harness the power of the immune system to fight cancer.